Side by side
5-Amino-1MQ vs Orforglipron
Both are discussed for weight loss. What this site records about each, side by side. Every figure is on the compound's own page with the source it came from.
| 5-Amino-1MQ | Orforglipron | |
|---|---|---|
| What it is | An oral NNMT inhibitor with striking results in obese mice and no human data whatsoever. Not a peptide, despite where it is sold. | The first GLP-1 pill that is a true small molecule. Approved in April 2026, and taken any time of day with no food or water restrictions. |
| EvidenceHow much human evidence exists, not how well it works. | Preclinical | Approved |
| Regulatory statusReviewed 2026-08-16 | Not approved anywhere, for any purpose, and never studied in a published human trial. Sold as a capsule, often labelled as a dietary supplement or a research chemical. Neither category requires evidence of effect or safety before sale. | Approved by the FDA on 1 April 2026 as Foundayo, for chronic weight management in adults with obesity, or overweight with a weight-related condition. The first non-peptide, small-molecule GLP-1 receptor agonist approved for weight loss. |
| Routes | Oral | Oral |
| Half-life | Not recorded | 30 hours |
| Cheapest per mgVials only, read from vendors' own listings and dated on the price index. | $0.94/mg | $40.00/mg |
| Median per mg | $2.00/mg | $40.00/mg |
| Vendors with a price | 37 | 1 |
| Storage once mixed | Not applicable. This is taken orally, not reconstituted. | Not applicable. This is a tablet. |
Compare two other compounds · The full price index
This page is educational. It describes what published research reports, not what you should do. Peptides discussed here are largely not approved for human use, and nothing on BioAlmanac is medical advice. Nothing here ranks these two against each other. A table can show that one has more human evidence behind it or costs less per milligram; neither of those is a recommendation, and the right comparison for any person is one their doctor makes with them.