Retatrutide with MOTS-c
Commonly runA triple incretin agonist next to a mitochondrial peptide, on the argument that losing weight fast is easier than losing it well. The second half has never finished a human trial.
- Retatrutide
- MOTS-c
16 weeks
Reference
Stacks
A stack is several compounds run together, each on its own dose and schedule. Combinations are discussed constantly and studied almost never, so every page here is explicit about where the evidence for the combination stops.
Check a combination against our interaction dataBuild and share your own
Documented stacks
Written and cited by us, with full schedules
CJC-1295, ipamorelin and MK-677
Commonly runThe two-receptor growth hormone pairing with an oral secretagogue stacked on top. Three compounds, two of them acting on the same receptor.
- CJC-1295
- Ipamorelin
- MK-677
12 weeks
BPC-157, TB-500 and GHK-Cu
Commonly runThe repair pairing with a copper peptide added for connective tissue. Three preclinical compounds, and the copper is the one with an actual ceiling.
- BPC-157
- TB-500
- GHK-Cu
10 weeks
A GLP-1 with 5-Amino-1MQ
Commonly runAn incretin agonist doing the established work, with an oral NNMT inhibitor added on a mechanism that has never been tested in a person. One half of this has phase 3 trials; the other half has mice.
- Retatrutide
- 5-Amino-1MQ
16 weeks
NAD+ with Epitalon
Commonly runThe commonly run longevity pairing, and the one where the two compounds' problems are different. NAD+ has a delivery problem; Epitalon has a replication problem.
- NAD+
- Epitalon
10 weeks
BPC-157 and TB-500
Commonly runThe most commonly run repair pairing. Two compounds on different schedules, on the reasoning that one builds blood supply and the other moves cells into the gap.
- BPC-157
- TB-500
8 weeks
CJC-1295 and Ipamorelin
Commonly runThe standard growth hormone pairing. Two compounds on two different receptors, which is the one combination in this category with a real mechanistic argument.
- CJC-1295
- Ipamorelin
12 weeks
Tesamorelin and Ipamorelin
Commonly runThe same two-receptor logic as CJC-1295 and ipamorelin, with the one GHRH analogue that has an approved indication behind it.
- Tesamorelin
- Ipamorelin
12 weeks
A GLP-1 agonist with an amylin analogue. The one combination in this category being developed as an actual drug, and the reason it earns a proper write-up.
- Semaglutide
- Cagrilintide
20 weeks
BPC-157 and GHK-Cu
Commonly runThe two components of GLOW without the TB-500, run separately so each can be dosed on its own schedule and route.
- GHK-Cu
- BPC-157
12 weeks
Shared by people running them
Individual people’s plans, published by them. We did not write them, check them, or verify anyone followed them — one person doing something is not evidence that it works.
Sort
Sleep depth on a rotating shift
8 wkProposedby nightshiftrnTwo compounds aimed at the same night from different ends: one at the sleep architecture itself, one at the growth hormone pulse that normally follows it. The honest caveat is that DSIP's human record is forty years old and small.
- DSIP
- Ipamorelin
Immune support through a heavy season
8 wkProposedby coastalrowerThe two thymic peptides, which is the one group on this site with a genuine clinical record — for hepatitis B and as an adjuvant, not for staying well through a training block. That gap is the whole point of reading the profiles first.
- Thymosin alpha-1
- Thymulin
Tendon and soft-tissue repair
6 wkProposedby mendtherapyThe most commonly described recovery pairing. BPC-157 runs throughout; TB-500 front-loads and then stops, which is the part most write-ups leave out.
- BPC-157
- TB-500
2 liked
See the schedule →Longevity course with a hard stop
6 wkProposedby quietlifterEpitalon is one of the few things here described as a short course rather than a standing dose. NAD+ continues past it. The stop is the point.
- Epitalon
- NAD+
1 liked
See the schedule →Skin repair and collagen signalling
8 wkProposedby northlabGHK-Cu is the one compound here with genuine cosmetic-science behind it, though topically rather than injected. BPC-157 is along for the repair side.
- GHK-Cu
- BPC-157
1 liked
See the schedule →Holding muscle through a deficit
16 wkProposedby coastalrowerA GLP-1 does not distinguish between fat and lean mass, and the trials report both coming off. This is the pairing people describe to protect the second, with the caveat that no trial has tested the combination.
- Semaglutide
- Ipamorelin
Mitochondrial output and NAD salvage
8 wkProposedby quietlifterMOTS-c and NAD+ get combined on the reasoning that one signals mitochondrial stress and the other supplies the coenzyme. That reasoning is plausible and untested in combination.
- MOTS-c
- NAD+
1 liked
See the schedule →Nasal focus without the stimulant edge
4 wkProposedby deskboundSemax and selank are the pairing most often described together, and the reason is that they pull in different directions — one for focus, one for the anxiety that focus compounds tend to bring. Neither has a completed Western trial.
- Semax
- Selank
Gut lining and systemic inflammation
8 wkProposedby mendtherapyBPC-157 for the gut work it was originally studied for, with KPV for the inflammatory side. Both are peptides with no completed human trial, which is the main thing to know.
- BPC-157
- KPV
Cognitive load over a long stretch
3 wkProposedby thesisyearSemax with a defined stop rather than a standing prescription, on the reasoning that a compound whose only endpoint is how you say you feel is the easiest kind to keep taking without noticing whether it does anything.
- Semax
- Noopept
Between training blocks
4 wkProposedby halfmarathonmikeRecovery in a deload week rather than during hard training. BPC-157 for connective tissue and KPV for the inflammatory load, both short.
- BPC-157
- KPV
Appetite and the amylin side
12 wkProposedby cutlerycrewSemaglutide with cagrilintide, which is the pairing the CagriSema trials tested as a single product. Worth reading both compound pages: this is the one combination here with real phase 3 behind it, and what is sold as a research chemical is not that product.
- Semaglutide
- Cagrilintide
Next
Where to go from a stack
- Check your own combinationPut in what you are running and see what our profiles record about every pair, including the pairs nothing is recorded about.
- Build one in the trackerGroup protocols into a plan, write notes as it runs, and publish it only if you decide to.
- Read the compounds firstEvery compound in every stack above has a profile stating what the evidence actually is.