Side by side
ACE-031 vs MK-677
Both are discussed for muscle & performance. What this site records about each, side by side. Every figure is on the compound's own page with the source it came from.
| ACE-031 | MK-677 | |
|---|---|---|
| What it is | A myostatin trap that reached phase 2 in Duchenne muscular dystrophy and was stopped there. The muscle effects were real but never reached significance; the reason it stopped was nosebleeds and spider veins. | An orally active ghrelin receptor agonist that raises growth hormone and IGF-1. Not a peptide, and not injected. It is a small molecule taken by mouth. |
| EvidenceHow much human evidence exists, not how well it works. | Early human trials | Early human trials |
| Regulatory statusReviewed 2026-09-01 | Never approved anywhere. Development was halted in 2011 on safety grounds and permanently discontinued in 2013. Prohibited in sport at all times by WADA as a myostatin inhibitor. Material sold as a research chemical is not the clinical product and carries none of the trial's monitoring. | Not approved for human use in any jurisdiction. Development was not completed. It is widely sold as a 'research chemical' or mislabelled as a dietary supplement, which it is not. It is an unapproved drug. |
| Routes | Subcutaneous | Oral |
| Half-life | Not recorded | 24 hours |
| Cheapest per mgVials only, read from vendors' own listings and dated on the price index. | $69.99/mg | $0.64/mg |
| Median per mg | $150.00/mg | $2.94/mg |
| Vendors with a price | 5 | 6 |
| Storage once mixed | Refrigerated at 2–8 °C. Proteins of this size are more fragile than short peptides — avoid shaking, which denatures them. | Not applicable. Liquid preparations sold in solution should follow the seller's storage instructions, which is a weaker guarantee than it sounds. |
Compare two other compounds · The full price index
This page is educational. It describes what published research reports, not what you should do. Peptides discussed here are largely not approved for human use, and nothing on BioAlmanac is medical advice. Nothing here ranks these two against each other. A table can show that one has more human evidence behind it or costs less per milligram; neither of those is a recommendation, and the right comparison for any person is one their doctor makes with them.