Side by side
Afamelanotide vs Melanotan II
Both are discussed for skin & hair. What this site records about each, side by side. Every figure is on the compound's own page with the source it came from.
| Afamelanotide | Melanotan II | |
|---|---|---|
| What it is | The approved member of the melanotan family. Same idea as melanotan II, taken through a full regulatory process, and the contrast between them is instructive. | A melanocortin agonist that darkens skin by stimulating melanin production. Carries the most serious dermatological concern of anything on this site. |
| EvidenceHow much human evidence exists, not how well it works. | Approved | Preclinical |
| Regulatory statusReviewed 2026-08-16 | Approved by the FDA (2019) and the EMA (2014) as Scenesse, a 16 mg subcutaneous implant for erythropoietic protoporphyria, inserted by a trained clinician every two months. Not approved for cosmetic tanning anywhere. Injectable powder sold as melanotan 1 is a research chemical — not the approved product — and does not share its delivery method, purity controls or supervision. | Not approved for human use in any jurisdiction. Multiple national medicines regulators have issued public safety warnings specifically about melanotan products, citing unregulated manufacture and dermatological risk. Sold only as a research chemical. |
| Routes | Subcutaneous | Subcutaneous |
| Half-life | 24 hours | 1 hours |
| Cheapest per mgVials only, read from vendors' own listings and dated on the price index. | $1.76/mg | $1.80/mg |
| Median per mg | $3.80/mg | $3.50/mg |
| Vendors with a price | 23 | 46 |
| Storage once mixed | Refrigerated at 2–8 °C. Do not freeze once mixed. | Refrigerated at 2–8 °C. Do not freeze once mixed. |
Compare two other compounds · The full price index
This page is educational. It describes what published research reports, not what you should do. Peptides discussed here are largely not approved for human use, and nothing on BioAlmanac is medical advice. Nothing here ranks these two against each other. A table can show that one has more human evidence behind it or costs less per milligram; neither of those is a recommendation, and the right comparison for any person is one their doctor makes with them.