Side by side
Follistatin-344 vs MK-677
Both are discussed for muscle & performance. What this site records about each, side by side. Every figure is on the compound's own page with the source it came from.
| Follistatin-344 | MK-677 | |
|---|---|---|
| What it is | A myostatin-blocking protein with dramatic animal results, no human trials, and a serious question over whether what is sold is the real thing. | An orally active ghrelin receptor agonist that raises growth hormone and IGF-1. Not a peptide, and not injected. It is a small molecule taken by mouth. |
| EvidenceHow much human evidence exists, not how well it works. | Preclinical | Early human trials |
| Regulatory statusReviewed 2026-08-16 | Not approved anywhere, and never studied in a human trial as an injectable protein. Follistatin gene therapy has been studied in small trials for muscular dystrophy. The most advanced pharmaceutical work on the myostatin pathway — using a different molecule — was halted for safety. | Not approved for human use in any jurisdiction. Development was not completed. It is widely sold as a 'research chemical' or mislabelled as a dietary supplement, which it is not. It is an unapproved drug. |
| Routes | Subcutaneous, Intramuscular | Oral |
| Half-life | Not recorded | 24 hours |
| Cheapest per mgVials only, read from vendors' own listings and dated on the price index. | $0.44/mg | $0.64/mg |
| Median per mg | $138.50/mg | $2.94/mg |
| Vendors with a price | 10 | 6 |
| Storage once mixed | Refrigerated at 2–8 °C, and used quickly. A large glycoprotein is far less stable in solution than a short peptide, and it will not look any different once it has lost activity. | Not applicable. Liquid preparations sold in solution should follow the seller's storage instructions, which is a weaker guarantee than it sounds. |
Compare two other compounds · The full price index
This page is educational. It describes what published research reports, not what you should do. Peptides discussed here are largely not approved for human use, and nothing on BioAlmanac is medical advice. Nothing here ranks these two against each other. A table can show that one has more human evidence behind it or costs less per milligram; neither of those is a recommendation, and the right comparison for any person is one their doctor makes with them.