Side by side
GHK-Cu vs MK-677
Both are discussed for anti-aging & longevity. What this site records about each, side by side. Every figure is on the compound's own page with the source it came from.
| GHK-Cu | MK-677 | |
|---|---|---|
| What it is | A naturally occurring copper-binding tripeptide with a long history in topical skincare research. Injected use is not what the research studied. | An orally active ghrelin receptor agonist that raises growth hormone and IGF-1. Not a peptide, and not injected. It is a small molecule taken by mouth. |
| EvidenceHow much human evidence exists, not how well it works. | Preclinical | Early human trials |
| Regulatory statusReviewed 2026-08-12 | Permitted as a topical cosmetic ingredient in the United States and widely sold as such. Not approved as an injectable medicine, and injectable material is a research chemical with no manufacturing standard behind it. | Not approved for human use in any jurisdiction. Development was not completed. It is widely sold as a 'research chemical' or mislabelled as a dietary supplement, which it is not. It is an unapproved drug. |
| Routes | Subcutaneous, Topical | Oral |
| Half-life | 1 hours | 24 hours |
| Cheapest per mgVials only, read from vendors' own listings and dated on the price index. | $0.28/mg | $0.64/mg |
| Median per mg | $0.60/mg | $2.94/mg |
| Vendors with a price | 63 | 6 |
| Storage once mixed | Refrigerated at 2–8 °C. The solution is characteristically blue; that colour is expected and is not a fault. | Not applicable. Liquid preparations sold in solution should follow the seller's storage instructions, which is a weaker guarantee than it sounds. |
Compare two other compounds · The full price index
This page is educational. It describes what published research reports, not what you should do. Peptides discussed here are largely not approved for human use, and nothing on BioAlmanac is medical advice. Nothing here ranks these two against each other. A table can show that one has more human evidence behind it or costs less per milligram; neither of those is a recommendation, and the right comparison for any person is one their doctor makes with them.