Side by side
Mazdutide vs Orforglipron
Both are discussed for weight loss. What this site records about each, side by side. Every figure is on the compound's own page with the source it came from.
| Mazdutide | Orforglipron | |
|---|---|---|
| What it is | A GLP-1 and glucagon dual agonist approved in China in 2026. Not approved in the United States, and the US pathway is undecided. | The first GLP-1 pill that is a true small molecule. Approved in April 2026, and taken any time of day with no food or water restrictions. |
| EvidenceHow much human evidence exists, not how well it works. | Approved for another indication | Approved |
| Regulatory statusReviewed 2026-08-18 | Approved in China in 2026 for weight management. Not approved by the FDA or the EMA, and a United States filing depends on a partnership decision rather than on further data. Material sold as a research chemical is not the approved Chinese product. | Approved by the FDA on 1 April 2026 as Foundayo, for chronic weight management in adults with obesity, or overweight with a weight-related condition. The first non-peptide, small-molecule GLP-1 receptor agonist approved for weight loss. |
| Routes | Subcutaneous | Oral |
| Half-life | 160 hours | 30 hours |
| Cheapest per mgVials only, read from vendors' own listings and dated on the price index. | $5.25/mg | $40.00/mg |
| Median per mg | $9.95/mg | $40.00/mg |
| Vendors with a price | 8 | 1 |
| Storage once mixed | Refrigerated at 2–8 °C. Do not freeze once mixed. | Not applicable. This is a tablet. |
Compare two other compounds · The full price index
This page is educational. It describes what published research reports, not what you should do. Peptides discussed here are largely not approved for human use, and nothing on BioAlmanac is medical advice. Nothing here ranks these two against each other. A table can show that one has more human evidence behind it or costs less per milligram; neither of those is a recommendation, and the right comparison for any person is one their doctor makes with them.