Side by side
MK-677 vs NAD+
Both are discussed for anti-aging & longevity. What this site records about each, side by side. Every figure is on the compound's own page with the source it came from.
| MK-677 | NAD+ | |
|---|---|---|
| What it is | An orally active ghrelin receptor agonist that raises growth hormone and IGF-1. Not a peptide, and not injected. It is a small molecule taken by mouth. | A coenzyme present in every cell, given by injection or infusion in the hope of raising cellular levels. Not a peptide, and poorly absorbed by the routes people use. |
| EvidenceHow much human evidence exists, not how well it works. | Early human trials | Early human trials |
| Regulatory statusReviewed 2026-08-12 | Not approved for human use in any jurisdiction. Development was not completed. It is widely sold as a 'research chemical' or mislabelled as a dietary supplement, which it is not. It is an unapproved drug. | Not approved as a medicine for any indication in the United States. Oral precursors are sold as dietary supplements; injectable NAD+ is compounded or sold as a research chemical and has no approval behind it. |
| Routes | Oral | Subcutaneous |
| Half-life | 24 hours | 0.5 hours |
| Cheapest per mgVials only, read from vendors' own listings and dated on the price index. | $0.64/mg | $0.04/mg |
| Median per mg | $2.94/mg | $0.12/mg |
| Vendors with a price | 6 | 65 |
| Storage once mixed | Not applicable. Liquid preparations sold in solution should follow the seller's storage instructions, which is a weaker guarantee than it sounds. | Refrigerated at 2–8 °C. Do not freeze once mixed. |
Compare two other compounds · The full price index
This page is educational. It describes what published research reports, not what you should do. Peptides discussed here are largely not approved for human use, and nothing on BioAlmanac is medical advice. Nothing here ranks these two against each other. A table can show that one has more human evidence behind it or costs less per milligram; neither of those is a recommendation, and the right comparison for any person is one their doctor makes with them.