Side by side
MK-677 vs Testosterone (TRT)
Both are discussed for muscle & performance. What this site records about each, side by side. Every figure is on the compound's own page with the source it came from.
| MK-677 | Testosterone (TRT) | |
|---|---|---|
| What it is | An orally active ghrelin receptor agonist that raises growth hormone and IGF-1. Not a peptide, and not injected. It is a small molecule taken by mouth. | Not a peptide, and the most consequential thing on this site. Approved replacement therapy for diagnosed hypogonadism — a Schedule III controlled substance — and something that will make you infertile while you take it. |
| EvidenceHow much human evidence exists, not how well it works. | Early human trials | Approved |
| Regulatory statusReviewed 2026-08-12 | Not approved for human use in any jurisdiction. Development was not completed. It is widely sold as a 'research chemical' or mislabelled as a dietary supplement, which it is not. It is an unapproved drug. | Approved by the FDA and EMA for diagnosed male hypogonadism, and a Schedule III controlled substance in the United States. Labelling was updated in 2025 following the TRAVERSE trial. Not approved for age-related decline in testosterone without a confirmed diagnosis. |
| Routes | Oral | Intramuscular, Subcutaneous, Topical |
| Half-life | 24 hours | 192 hours |
| Cheapest per mgVials only, read from vendors' own listings and dated on the price index. | $0.64/mg | Not recorded |
| Median per mg | $2.94/mg | Not recorded |
| Vendors with a price | 6 | Not recorded |
| Storage once mixed | Not applicable. Liquid preparations sold in solution should follow the seller's storage instructions, which is a weaker guarantee than it sounds. | Nothing to reconstitute. A multi-dose vial is good until its expiry if the stopper is cleaned before each draw. |
Compare two other compounds · The full price index
This page is educational. It describes what published research reports, not what you should do. Peptides discussed here are largely not approved for human use, and nothing on BioAlmanac is medical advice. Nothing here ranks these two against each other. A table can show that one has more human evidence behind it or costs less per milligram; neither of those is a recommendation, and the right comparison for any person is one their doctor makes with them.