Side by side
MK-677 vs Vesugen
Both are discussed for anti-aging & longevity. What this site records about each, side by side. Every figure is on the compound's own page with the source it came from.
| MK-677 | Vesugen | |
|---|---|---|
| What it is | An orally active ghrelin receptor agonist that raises growth hormone and IGF-1. Not a peptide, and not injected. It is a small molecule taken by mouth. | The vascular peptide of the family, described in the originating work as supporting the endothelium. One institute, four decades, no outside replication. |
| EvidenceHow much human evidence exists, not how well it works. | Early human trials | Preclinical |
| Regulatory statusReviewed 2026-08-12 | Not approved for human use in any jurisdiction. Development was not completed. It is widely sold as a 'research chemical' or mislabelled as a dietary supplement, which it is not. It is an unapproved drug. | Not approved for human use in the United States, the European Union or the United Kingdom. Some peptides in this family are registered in Russia as supplements or medicines. Vesugen is sold elsewhere as a research chemical. |
| Routes | Oral | Subcutaneous, Oral |
| Half-life | 24 hours | Not recorded |
| Cheapest per mgVials only, read from vendors' own listings and dated on the price index. | $0.64/mg | $1.79/mg |
| Median per mg | $2.94/mg | $3.08/mg |
| Vendors with a price | 6 | 10 |
| Storage once mixed | Not applicable. Liquid preparations sold in solution should follow the seller's storage instructions, which is a weaker guarantee than it sounds. | Refrigerated at 2–8 °C. Do not freeze once mixed. |
Compare two other compounds · The full price index
This page is educational. It describes what published research reports, not what you should do. Peptides discussed here are largely not approved for human use, and nothing on BioAlmanac is medical advice. Nothing here ranks these two against each other. A table can show that one has more human evidence behind it or costs less per milligram; neither of those is a recommendation, and the right comparison for any person is one their doctor makes with them.