Bioalmanac
Cagrilintide
AM833 · Cagri
A long-acting amylin analogue in late-stage trials. It works on a different satiety pathway from the GLP-1 drugs. Which is why it is being developed alongside semaglutide rather than against it.
Storage
- Freeze-dried powder
- Refrigerated at 2–8 °C, protected from light.
- After mixing
- Refrigerated at 2–8 °C. Do not freeze once mixed.
- Long-term, frozen
- Unopened powder is stable at −20 °C or colder.
Reconstitution — 5 mg vial, 2400 mcg dose
On a 1 mL U-100 syringe. Check every figure against your own vial before drawing.
| Water added | Concentration | Volume to draw | Units | Doses per vial |
|---|---|---|---|---|
| 1 mL | 5 mg/mL | 0.48 mL | 48 units | 2.1 |
| 2 mL | 2.5 mg/mL | 0.96 mL | 96 units | 2.1 |
| 3 mL | 1.667 mg/mL | — | Exceeds a 1 mL barrel | — |
| 5 mL | 1 mg/mL | — | Exceeds a 1 mL barrel | — |
Dose ranges reported in sources
Descriptions of what sources report, not recommendations.
| Goal | Range | Frequency | Source |
|---|---|---|---|
| Phase 2 escalation, single agent | 300–4500 mcg | Once weekly, escalating over several weeks | Clinical trial |
| Combination with semaglutide, as studied | 2400 mcg | Once weekly | Clinical trial |
When to stop
- Vomiting severe enough that you cannot keep fluids down. Dehydration is the acute risk.
- Severe, persistent abdominal pain, particularly radiating to the back.
- Losing weight faster than roughly 1% of body weight per week, or being unable to eat adequately. Rapid loss costs muscle and raises gallstone risk.
- Any allergic response: rash, hives, facial swelling or difficulty breathing. Seek urgent care.
- Signs of low blood sugar if you also use insulin or a sulfonylurea.
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