Bioalmanac
FOXO4-DRI
FOXO4-D-Retro-Inverso · Senolytic peptide
A senolytic peptide that made aged mice regrow fur and recover kidney function. One landmark paper, no human trial, and it works by making cells kill themselves.
Storage
- Freeze-dried powder
- Refrigerated at 2–8 °C, protected from light.
- After mixing
- Refrigerated at 2–8 °C. Do not freeze once mixed.
- Long-term, frozen
- Unopened powder is stable at −20 °C or colder.
Reconstitution — 10 mg vial, 2000 mcg dose
On a 1 mL U-100 syringe. Check every figure against your own vial before drawing.
| Water added | Concentration | Volume to draw | Units | Doses per vial |
|---|---|---|---|---|
| 1 mL | 10 mg/mL | 0.2 mL | 20 units | 5 |
| 2 mL | 5 mg/mL | 0.4 mL | 40 units | 5 |
| 3 mL | 3.333 mg/mL | 0.6 mL | 60 units | 5 |
| 5 mL | 2 mg/mL | 1 mL | 100 units | 5 |
Dose ranges reported in sources
Descriptions of what sources report, not recommendations.
| Goal | Range | Frequency | Source |
|---|---|---|---|
| Commonly described community protocol | 1000–5000 mcg | Every other day for a short course, repeated rarely | Community practice |
When to stop
- Any acute reaction: fever, breathlessness, chest pain. Seek urgent care.
- Any allergic response: rash, hives, facial swelling or difficulty breathing. Seek urgent care.
- Any new lump or unexplained persistent symptom.
- An injection site that becomes hot, spreading or produces pus.
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