Bioalmanac
Kisspeptin-10
KP-10 · Metastin 45-54 · KISS1-derived peptide
The master switch above the reproductive hormone axis. Unusually for this category, it has a serious academic research programme in humans behind it.
Storage
- Freeze-dried powder
- Refrigerated at 2–8 °C, protected from light.
- After mixing
- Refrigerated at 2–8 °C. Do not freeze once mixed.
- Long-term, frozen
- Unopened powder is stable at −20 °C or colder.
Reconstitution — 5 mg vial, 200 mcg dose
On a 1 mL U-100 syringe. Check every figure against your own vial before drawing.
| Water added | Concentration | Volume to draw | Units | Doses per vial |
|---|---|---|---|---|
| 1 mL | 5 mg/mL | 0.04 mL | 4 units | 25 |
| 2 mL | 2.5 mg/mL | 0.08 mL | 8 units | 25 |
| 3 mL | 1.667 mg/mL | 0.12 mL | 12 units | 25 |
| 5 mL | 1 mg/mL | 0.2 mL | 20 units | 25 |
Dose ranges reported in sources
Descriptions of what sources report, not recommendations.
| Goal | Range | Frequency | Source |
|---|---|---|---|
| Provocative test of the reproductive axis, as studied | 100–1000 mcg | A single dose or a short infusion | Clinical trial |
| Commonly described community protocol | 100–500 mcg | Daily or several times weekly | Community practice |
When to stop
- Any allergic response: rash, hives, facial swelling or difficulty breathing. Seek urgent care.
- A fall in libido, testicular size or morning erections. All three suggest the axis is being suppressed rather than stimulated.
- Changes to menstrual cycle.
- Persistent flushing, headache or nausea.
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