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Bioalmanac

MOTS-c

Mitochondrial ORF of the 12S rRNA type-c

Preclinical

Status reviewed 12 Aug 2026

Prohibited in sport

A 16-amino-acid peptide encoded by mitochondrial rather than nuclear DNA, studied in animals for effects on metabolism and exercise capacity.

Storage

Freeze-dried powder
Refrigerated at 2–8 °C, protected from light.
After mixing
Refrigerated at 2–8 °C. Do not freeze once mixed.
Long-term, frozen
Unopened powder is stable at −20 °C or colder.

Reconstitution — 10 mg vial, 5000 mcg dose

On a 1 mL U-100 syringe. Check every figure against your own vial before drawing.

Water addedConcentrationVolume to drawUnitsDoses per vial
1 mL10 mg/mL0.5 mL50 units2
2 mL5 mg/mL1 mL100 units2
3 mL3.333 mg/mLExceeds a 1 mL barrel
5 mL2 mg/mLExceeds a 1 mL barrel

Dose ranges reported in sources

Descriptions of what sources report, not recommendations.

GoalRangeFrequencySource
Commonly described dose5000–10000 mcgTwo or three times weeklyCommunity practice

When to stop

  • Symptoms of low blood sugar — shakiness, sweating, confusion, unusual hunger — particularly if they recur.
  • Any allergic response: rash, hives, facial swelling or difficulty breathing. Seek urgent care.
  • Signs of infection at an injection site.
  • Any new or unexplained symptom you would ordinarily see a doctor about.

Not approved for human use in the United States. Sold only as a research chemical.

Arithmetic on values you enter. Not medical advice. Not reviewed by a clinician. · bioalmanac.com/peptides/mots-c

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