Bioalmanac
PE-22-28
Mini-spadin · Spadin analogue
A spadin-derived peptide targeting a potassium channel. A genuinely novel antidepressant mechanism, demonstrated in mice and nowhere else.
Storage
- Freeze-dried powder
- Refrigerated at 2–8 °C, protected from light.
- After mixing
- Refrigerated at 2–8 °C. Nasal solutions are handled more than injectables and are correspondingly easier to contaminate.
- Long-term, frozen
- Unopened powder is stable at −20 °C or colder.
Reconstitution — 10 mg vial, 500 mcg dose
On a 1 mL U-100 syringe. Check every figure against your own vial before drawing.
| Water added | Concentration | Volume to draw | Units | Doses per vial |
|---|---|---|---|---|
| 1 mL | 10 mg/mL | 0.05 mL | 5 units | 20 |
| 2 mL | 5 mg/mL | 0.1 mL | 10 units | 20 |
| 3 mL | 3.333 mg/mL | 0.15 mL | 15 units | 20 |
| 5 mL | 2 mg/mL | 0.25 mL | 25 units | 20 |
Dose ranges reported in sources
Descriptions of what sources report, not recommendations.
| Goal | Range | Frequency | Source |
|---|---|---|---|
| Commonly described community protocol | 200–800 mcg | Once daily, often in short courses | Community practice |
When to stop
- Worsening mood, agitation, or any thought of harming yourself. Seek help immediately.
- Palpitations or an irregular heartbeat.
- Any new neurological symptom, including seizure activity.
- Any allergic response: rash, hives, facial swelling or difficulty breathing. Seek urgent care.
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