Bioalmanac
Semaglutide
GLP-1 receptor agonist · NN9535
A long-acting GLP-1 receptor agonist approved for type 2 diabetes and for weight management, dosed once weekly.
Storage
- Freeze-dried powder
- Refrigerated at 2–8 °C and protected from light. Stable for far longer than the reconstituted form.
- After mixing
- Refrigerated at 2–8 °C. Do not freeze. Discard if the solution is cloudy or has visible particles.
- Long-term, frozen
- Unopened lyophilised powder is stable at −20 °C or colder.
Reconstitution — 5 mg vial, 250 mcg dose
On a 1 mL U-100 syringe. Check every figure against your own vial before drawing.
| Water added | Concentration | Volume to draw | Units | Doses per vial |
|---|---|---|---|---|
| 1 mL | 5 mg/mL | 0.05 mL | 5 units | 20 |
| 2 mL | 2.5 mg/mL | 0.1 mL | 10 units | 20 |
| 3 mL | 1.667 mg/mL | 0.15 mL | 15 units | 20 |
| 5 mL | 1 mg/mL | 0.25 mL | 25 units | 20 |
Dose ranges reported in sources
Descriptions of what sources report, not recommendations.
| Goal | Range | Frequency | Source |
|---|---|---|---|
| Trial escalation, weeks 1–4 | 250 mcg | Once weekly | Clinical trial |
| Trial escalation, weeks 5–16 | 500–1700 mcg | Once weekly, raised in steps every four weeks | Clinical trial |
| Trial maintenance dose | 2400 mcg | Once weekly | Clinical trial |
When to stop
- Severe, persistent abdominal pain, especially radiating to the back and with vomiting. That is the presentation of pancreatitis. Seek urgent medical care.
- Persistent vomiting or inability to keep fluids down. Dehydration is the most common route to serious trouble on these drugs.
- Signs of gallbladder disease: pain in the upper right abdomen, fever, or yellowing of the skin or eyes.
- A lump or swelling in the neck, hoarseness, or difficulty swallowing.
- Any allergic response: rash, hives, facial swelling, or difficulty breathing. Seek urgent care.
- If you become pregnant or are planning to.
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