Bioalmanac
TB-500
Thymosin beta-4 fragment · TB4 fragment
A synthetic fragment of thymosin beta-4, a naturally occurring protein involved in cell migration and tissue repair. Animal evidence only.
Storage
- Freeze-dried powder
- Refrigerated at 2–8 °C, protected from light.
- After mixing
- Refrigerated at 2–8 °C. Do not freeze once mixed.
- Long-term, frozen
- Unopened lyophilised powder is stable at −20 °C or colder for considerably longer than refrigeration allows.
Reconstitution — 5 mg vial, 2500 mcg dose
On a 1 mL U-100 syringe. Check every figure against your own vial before drawing.
| Water added | Concentration | Volume to draw | Units | Doses per vial |
|---|---|---|---|---|
| 1 mL | 5 mg/mL | 0.5 mL | 50 units | 2 |
| 2 mL | 2.5 mg/mL | 1 mL | 100 units | 2 |
| 3 mL | 1.667 mg/mL | — | Exceeds a 1 mL barrel | — |
| 5 mL | 1 mg/mL | — | Exceeds a 1 mL barrel | — |
Dose ranges reported in sources
Descriptions of what sources report, not recommendations.
| Goal | Range | Frequency | Source |
|---|---|---|---|
| Loading, commonly described | 2000–5000 mcg | Twice weekly for the first four to six weeks | Community practice |
| Maintenance, commonly described | 2000–2500 mcg | Once weekly or every other week | Community practice |
When to stop
- Signs of infection at an injection site: spreading redness, warmth, swelling, pus, or fever.
- Any allergic response: rash, hives, facial or lip swelling, or difficulty breathing. Seek urgent care.
- Any new lump, growth or unexplained change you would ordinarily have investigated.
- Before planned surgery, and tell your surgical team.
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