2 mg vial
Semaglutide: a 2 mg vial
What a 2 mg vial of Semaglutide becomes once it is mixed, and what each dose reported in the sources draws to on a syringe. Every figure is arithmetic on the vial size in the heading — none of it is a recommendation, and the doses are the ones our sources describe rather than ones we picked.
Leading with
2 mg + 1 mL bacteriostatic water = 2 mg/mL
Chosen because it puts the reported doses on readable marks of a 1 mL U-100 syringe. Other volumes are perfectly valid — the dilution table further down covers them, and the concentration changes what every dose draws to.
What each reported dose draws to
At 2 mg/mL, on a 1 mL U-100 syringe. Every row names the source it came from, and a trial protocol and a community convention are not the same kind of information.
| Goal | Dose | Units | Doses in this vial | Source |
|---|---|---|---|---|
| Trial escalation, weeks 1–4Once weekly · Subcutaneous | 250 mcg | 12.5 units | 8 | Clinical trial |
| Trial escalation, weeks 5–16Once weekly, raised in steps every four weeks · Subcutaneous | 500 mcg – 1.7 mg | 25 units – 85 units | 4 | Clinical trial |
| Trial maintenance doseOnce weekly · Subcutaneous | 2.4 mg | More than one vial per dose | — | Clinical trial |
CheckSome doses above need more compound than a 2 mg vial holds, so one dose spans more than one vial. A larger vial is usually the cheaper and more accurate answer than combining two.
Check every figure against the vial in front of you before drawing. Vials are filled with an overage and labels are not a guarantee. Change any of these numbers in the calculator.
Week by week
Published schedules only. Most compounds on this site have no week-by-week schedule from any source, and where that is the case this section does not appear rather than being filled in.
Trial and label escalation
Approved label| Week | Dose | Units | Frequency |
|---|---|---|---|
| 1–4 | 250 mcg | 12.5 units | Once weeklyStarting dose, below the therapeutic range. |
| 5–8 | 500 mcg | 25 units | Once weekly |
| 9–12 | 1 mg | 50 units | Once weekly |
| 13–16 | 1.7 mg | 85 units | Once weekly |
| 17+ | 2.4 mg | Exceeds this vial | Once weeklyMaintenance dose used for the remainder of the 68-week trial. |
The label allows a step to be held for longer than four weeks if the current dose is not tolerated, rather than requiring the schedule be abandoned.
What the whole schedule costs
Vials of this size needed to work through each step, at 1 mL per vial. The dose changes as you go, so this is not one number times a number of weeks — it is each step costed separately and added up.
Trial and label escalation
| Week | Dose | Doses | 2 mg vials |
|---|---|---|---|
| 1–4 | 250 mcg | 4 | 1 |
| 5–8 | 500 mcg | 4 | 1 |
| 9–12 | 1 mg | 4 | 2 |
| 13–16 | 1.7 mg | 4 | 4 |
| 17+ | 2.4 mg | — | More than one per dose |
Reaching the end of the defined steps takes 8 vials of 2 mg over 16 weeks, and the last step continues indefinitely, so that is a floor rather than a total.
Steps whose dose exceeds this vial are marked rather than counted — at that point a larger vial is the answer, not more small ones. Nothing here accounts for a dropped vial, a held step or a dose your prescriber changes, all of which happen.
If you add a different amount of water
The same 2 mg of compound, at four common volumes. More water means a larger, easier-to-measure draw of a weaker solution; less water means the opposite. The amount of compound you inject is identical in every row — only the volume carrying it changes.
| Water added | Concentration | 250 mcg draws to |
|---|---|---|
| 1 mLshown above | 2 mg/mL | 12.5 units units · 0.125 mL |
| 2 mL | 1 mg/mL | 25 units units · 0.25 mL |
| 3 mL | 0.667 mg/mL | 37.5 units units · 0.375 mL |
| 5 mL | 0.4 mg/mL | 62.5 units units · 0.625 mL |
Storage
Before mixing
Refrigerated at 2–8 °C and protected from light. Stable for far longer than the reconstituted form.
After mixing
Refrigerated at 2–8 °C. Do not freeze. Discard if the solution is cloudy or has visible particles.
Other vial sizes
The same compound, different arithmetic.
Arithmetic on the vial size named above and the doses our sources report. Nothing here is a recommendation, a protocol or medical advice, and no clinician has reviewed it. Speak to a licensed healthcare provider before acting on any of it.
Sources for the doses above are listed in full on the Semaglutide profile, each with the trial or label it came from.