Side by side
Cyclic Glycine-Proline vs N-Acetyl Semax Amidate
Both are discussed for cognition & mood. What this site records about each, side by side. Every figure is on the compound's own page with the source it came from.
| Cyclic Glycine-Proline | N-Acetyl Semax Amidate | |
|---|---|---|
| What it is | A naturally occurring metabolite of IGF-1 that appears to regulate how much IGF-1 is available, which is the opposite of supplying more of it. | Semax with both ends chemically capped so it lasts longer. More potent per milligram in animal work, and no human trial of the modified version exists. |
| EvidenceHow much human evidence exists, not how well it works. | Preclinical | Preclinical |
| Regulatory statusReviewed 2026-08-18 | Not approved as a medicine anywhere. It occurs naturally in the body and in some foods, and is sold as a supplement in some markets and as a research chemical elsewhere. No interventional human trial has been published. | Not approved anywhere. Semax itself is registered in Russia; this modified version is not, and has never been through a human trial. Sold only as a research chemical. |
| Routes | Oral | Nasal, Subcutaneous |
| Cheapest per mgVials only, read from vendors' own listings and dated on the price index. | Not recorded | $3.25/mg |
| Median per mg | Not recorded | $3.50/mg |
| Vendors with a price | Not recorded | 4 |
| Storage once mixed | Refrigerated if made into solution, and used within days. | Refrigerated at 2–8 °C. Nasal solutions are handled more than injectables and are correspondingly easier to contaminate. |
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This page is educational. It describes what published research reports, not what you should do. Peptides discussed here are largely not approved for human use, and nothing on BioAlmanac is medical advice. Nothing here ranks these two against each other. A table can show that one has more human evidence behind it or costs less per milligram; neither of those is a recommendation, and the right comparison for any person is one their doctor makes with them.