Is it better than Semax?

More potent per milligram in animals. That is not the same as better. Semax has decades of Russian clinical use; the amidated version has never been given to a person in a study.

What do the modifications actually do?

They cap both ends of the peptide against the enzymes that would chew it up, so it lasts longer. They do not change what it binds to.

Anti-aging & longevity

N-Acetyl Semax Amidate

NA-Semax-Amidate · NASA · Semax amidate

PreclinicalReviewed 18 Aug 2026

This is Semax with two changes: an acetyl group added to one end and an amide to the other. Both exist for the same reason. Peptides are broken down from their ends by enzymes, and capping them slows that down.

The result is described as more potent and longer-lasting than Semax, and the animal work supports that in the narrow sense of requiring less material for the same effect. What does not exist is a human trial of the modified molecule. Semax itself has Russian registration and decades of clinical use behind it; this version has neither.

That distinction is the whole page. Buying this instead of Semax means trading a compound with a genuine, if hard-to-evaluate, clinical record for one with an animal-derived potency claim and nothing else.

How it works

Semax is a fragment of ACTH with the hormonal activity removed, and it is understood to raise BDNF, brain-derived neurotrophic factor, along with affecting the dopamine and serotonin systems. The amidated version is presumed to do the same things.

The terminal modifications do not change what the molecule binds. They change how long it survives before peptidases cut it apart, which is why the potency difference is a duration difference, not a mechanistic one.

Longer-lasting is not automatically better for a compound acting on neurotransmitter systems. Nothing establishes what a sustained version of a pulsed effect does, and that question has not been asked.

Quick reference

Commonly described dose: 300 mcg–900 mcg
How often: Once or twice daily
Route: Nasal or Subcutaneous
Where: Nasal
Timing: Most often described in the morning.
Storage once mixed: Refrigerated, 21 days

These describe what sources report, not what you should do. Full detail and provenance in the dosing section below.

Price index

Per-milligram pricing across vendors arrives with the directory. We are recording prices now so the history exists when the page ships.

Vocabulary on this page

Duration of action: How long an effect lasts. This is not the same as half-life and often much longer.
Concentration: How much peptide there is in each millilitre of solution, once the vial has been reconstituted.
Evidence level: The category of human evidence behind a compound, from preclinical through to approved. Stated on every profile here as a category, not an adjective.
Peptide: A short chain of amino acids: the same building blocks as a protein, in a chain short enough to behave differently.

The whole glossary →

Regulatory status — United States

Not approved anywhere. Semax itself is registered in Russia; this modified version is not, and has never been through a human trial. Sold only as a research chemical.

Last reviewed 18 Aug 2026. Regulatory positions in this category change frequently; we date this line so you can see how current it is.

What it is studied for

Each entry states the evidence behind it. We do not rank indications by effectiveness — for most compounds here, that would be a claim nobody can support.

Cognition, focus and neuroprotection

Community practice

Why it is bought.

EvidenceAnimal work suggests greater potency than Semax. No human trial of the amidated form has been conducted.

Identity and clearance

Molecule

Class: N-acetylated, C-amidated analogue of Semax
Length: 7 amino acids

Same backbone as Semax with both termini capped against enzymatic degradation.

Dose protocols reported in sources

Displayed for reference only. Every row says where it came from, and a trial protocol and a community convention are not the same kind of information. None of this is fed into the calculator, and none of it is a recommendation.

Dose protocols reported in sources, with the source of each.
Goal	Dose	Frequency	Route	Units, 10 mg vial	Source	Start this protocol
Commonly described community protocol	300 mcg – 900 mcg	Once or twice daily	NasalLower than Semax figures, on the reasoning that the modified form is more potent. That reasoning comes from animal work and no human study establishes an equivalence.	15–45 u	Community practice	Start this

Start this copies a row into a protocol of your own, which you can then edit. Where a source gave a dose range or an ambiguous frequency, those fields arrive empty — we will not pick a number on your behalf.

CheckRows marked community practice describe what people commonly do, drawn from public discussion. They are not derived from any trial and are not evidence that a dose is safe or effective.

Calculator

Work out what to draw

Pre-filled with a 30 mg vial as a worked example. These are not recommended values — change them to match the vial in front of you.

Draw to 6 units on a 1 mL U-100 syringe. That is 0.06 mL, containing 600 mcg of N-Acetyl Semax Amidate.

Concentration10mg / mL

Volume drawn0.06mL

Doses per vial50doses

Per unit100mcg / unit

6 units sits exactly on a printed line.

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Bioalmanac performs arithmetic on values you enter. It does not recommend doses, schedules or compounds, and nothing here is medical advice. Confirm every calculation against your vial and syringe before drawing, and speak with a licensed healthcare provider.

Open this calculation in the full calculator

Units, concentration, bacteriostatic water — the glossary defines the vocabulary, and a unit is not a fixed volume.

Safety

Reported effects

Nasal irritationCommunity practice
Commonly reported
Overstimulation, irritability and disturbed sleepCommunity practice
Commonly reported
More often described than with Semax, which is consistent with a longer-acting version of the same effect.
Everything elseCommunity practice
Unknown
The modified molecule has never been studied in a person.

When to stop

Sleep disturbance that does not settle, or worsening anxiety or irritability.
Persistent headache.
Nasal pain, bleeding or discharge.
Any allergic response: rash, hives, facial swelling or difficulty breathing. Seek urgent care.

Interactions and situations that need care

Any psychiatric conditionAvoid
A longer-acting compound affecting dopamine and serotonin systems — with no human data — is not something to add to a condition already being managed with drugs that act on the same systems.
Pregnancy and breastfeedingAvoid
No reproductive or developmental safety data.
Substituting it for Semax on the potency claimUse caution
Semax has a Russian clinical record; this does not. Trading a compound with some human evidence for one with none, on the strength of an animal potency figure, is the opposite of what the potency claim seems to promise.

What to expect

HonestlyThere is no human efficacy data for this compound, so there is no evidence-based timeline to give. Any site publishing a week-by-week schedule of expected effects has invented it.

No human trial of this molecule exists. The evidence people cite is for Semax, which is a different compound.
The modification changes how long it lasts, not what it does.
Overstimulation and sleep disruption are reported more often than with Semax. That is what a longer-acting version would predict.
If the Russian clinical record is what attracts you, that record belongs to Semax.

Storage and handling

Freeze-dried powder: Refrigerated at 2–8 °C, protected from light.
After mixing: Refrigerated at 2–8 °C. Nasal solutions are handled more than injectables and are correspondingly easier to contaminate.
Long-term, frozen: Unopened powder is stable at −20 °C or colder.

Printable one-pager How to reconstitute a vial, step by step

With other peptides

Semaxcaution
This is a modified Semax. Running both is taking the same compound twice, once in a form with human clinical use behind it and once in a form with none.

Check this against a whole stack

Checking your vial

Research chemicals carry no manufacturing standard, so what the vial looks like is often the only quality signal available before you use it. More on assessing quality and COAs.

White cake, clear solution
Standard for a short peptide.
Collapsed cake or cloudy solution
Heat damage or degradation. Do not use it.

Questions

Is it better than Semax?: More potent per milligram in animals. That is not the same as better. Semax has decades of Russian clinical use; the amidated version has never been given to a person in a study.
What do the modifications actually do?: They cap both ends of the peptide against the enzymes that would chew it up, so it lasts longer. They do not change what it binds to.

References

Russian clinical literature on regulatory peptides and nootropics: scope and limits
Russian pharmacology and psychiatry literature, 2015 · Body of clinical work, largely unregistered and not blinded to contemporary standards
Humans
Reports anxiolytic, nootropic and neuroprotective effects supporting registration of several of these compounds in Russia. Methodology, reporting standards and the absence of independent replication limit how much weight the findings carry elsewhere.
Commonly reported community protocols
Bioalmanac editorial summary of public community sources, 2026 · Not a study
Records dose and route patterns described in public discussion. Carries no evidential weight about safety or effect.

Related compounds

Semax

A seven-amino-acid peptide developed in Russia and approved there for stroke and cognitive indications. It holds no approval elsewhere and is used nasally rather than injected.

GHK-Cu

A naturally occurring copper-binding tripeptide with a long history in topical skincare research. Injected use is not what the research studied.

Ipamorelin

A selective growth hormone secretagogue that prompts a short pulse of GH release. Widely used, and supported almost entirely by early pharmacology rather than outcome trials.

CJC-1295

A GHRH analogue that raises growth hormone by amplifying the body's own release signal. Sold in two forms whose durations differ by two orders of magnitude.

Keep this page honest

If something here is wrong, out of date, or missing a source, tell us and we will fix it and say that we did.

Suggest a correction

This page is educational. It describes what published research reports, not what you should do. Peptides discussed here are largely not approved for human use, and nothing on Bioalmanac is medical advice. No clinician reviews these pages.

Page last updated 18 Aug 2026