Is there human evidence for BPC-157?

There are no completed, published, controlled human trials establishing that it works or that it is safe. One small uncontrolled pilot in interstitial cystitis with twelve participants exists. The rest of the evidence base is animal studies, largely from a small number of research groups, without independent replication in people.

Why is it sold as a research chemical?

Because it is not an approved medicine. That label means the material has not been manufactured, tested or labelled to any pharmaceutical standard, and purity and identity vary between sellers.

How is BPC-157 usually reconstituted?

A 5 mg vial mixed with 2 mL of bacteriostatic water gives 2.5 mg per mL, which puts a 250 mcg dose at 10 units on a 1 mL U-100 syringe. Use the calculator on this page to check your own numbers against your own vial.

Does injecting near the injury actually matter?

It is very commonly recommended in community sources, on the reasoning that the effect is local. No human study has compared injecting near an injury against injecting elsewhere, so this is a plausible idea, not an established one.

BPC-157

Body Protection Compound-157PL 14736Pentadecapeptide BPC 157

PreclinicalProhibited in sport

Evidence

Preclinical

Half-life

4 h

Typical vial

2 mg

Route

2 routes

What it is

A synthetic 15-amino-acid peptide studied in animals for effects on tendon, ligament and gut tissue repair. No completed human trials.

Reviewed 12 Aug 2026

BPC-157 is a laboratory-made sequence of fifteen amino acids derived from a larger protein found in human gastric juice. It does not occur in the body in this form. The fragment is synthetic, and the parent protein's own role is not fully characterised.

Nearly all published work is preclinical: cell cultures and rodent models, largely from a small number of research groups. Reported findings include faster healing of injured tendon and muscle tissue in rats and protective effects on the gut lining. Independent replication in humans is the thing that is missing, and it is a substantial gap, not a technicality. Nothing below should be read as an expected outcome in a person.

It is worth being precise about what 'extensively researched' means here, because the phrase appears often. There is a large volume of published work, and almost none of it is in humans. Volume of papers and weight of evidence are not the same measurement.

How it works

The most frequently proposed mechanism is angiogenic: BPC-157 appears to promote the formation of new blood vessels in injured tissue in animal models, partly by upregulating receptors involved in vascular growth. More blood supply to a healing site plausibly means faster repair.

Other reported effects include interaction with nitric oxide signalling and with growth factor pathways involved in collagen formation. These are proposed mechanisms drawn from animal experiments — not established pharmacology — and how they would translate to humans is unknown.

What it is studied for

Each entry states the evidence behind it. We do not rank indications by effectiveness — for most compounds here, that would be a claim nobody can support.

Tendon and ligament repair
Published review
The most commonly discussed use, and the one with the most supporting animal work.
EvidenceRat models of tendon and ligament injury report faster healing and improved mechanical strength. No human trials.
Gut and gastric protection
Published review
Reported protective effects on the stomach and intestinal lining.
EvidenceRodent models of induced gastric injury. One small human pilot in interstitial cystitis exists; it was uncontrolled and had twelve participants.
Muscle injury recovery
Published review
Discussed for recovery from crush and strain injuries.
EvidenceAnimal models only.

Regulatory status

Last reviewed 12 Aug 2026. Positions in this category change frequently, so we date the line.

United States

Not approved for human use in the United States. The FDA has treated BPC-157 as a substance raising safety concerns for use in compounded preparations. Material sold online is a research chemical with no manufacturing standard behind it.

Identity and clearance

What the molecule is, and how long a dose stays measurable.

Published review

Molecule

Class: Pentadecapeptide
Molecular weight: 1419.53 Da
Length: 15 amino acids

Sequence

Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val

A partial sequence of the human gastric protein BPC. The fragment is synthetic and does not occur in the body on its own.

Pharmacokinetics

Published review

Peak1 h

Half-life4 h

Substantially cleared20 h

Modelled from the half-life above, assuming first-order elimination. Illustrative rather than measured — it shows the shape of clearance, not a prediction for any individual.

Derived from animal work. No human pharmacokinetic study has been published, so these figures should be treated as indicative rather than established.

Dose protocols reported in sources

Displayed for reference only. Every row says where it came from, and a trial protocol and a community convention are not the same kind of information. None of this is fed into the calculator, and none of it is a recommendation.

Mixed sources

A week-by-week progression is also reported for BPC-157. See it against a 2 mg vial, where the syringe units can be worked out.

Dose protocols reported in sources, with the source of each.
Goal	Dose	Frequency	Route	Units, 2 mg vial	Source	Start this protocol
Tendon or joint injury	250 mcg – 500 mcg	Once or twice daily	SubcutaneousCommunity sources commonly favour injecting near the injury site, on the reasoning that the effect is local. This has not been tested against injection elsewhere in humans.	12.5–25 u	Community practice	Start this
General recovery	250 mcg – 500 mcg	Once daily	Subcutaneous	12.5–25 u	Community practice	Start this
Lower-end maintenance	200 mcg – 250 mcg	Once daily	Subcutaneous	10–12.5 u	Community practice	Start this

The doses above in syringe units, for the vial you have:

Start this copies a row into a protocol of your own, which you can then edit. Where a source gave a dose range or an ambiguous frequency, those fields arrive empty — we will not pick a number on your behalf.

CheckRows marked community practice describe what people commonly do, drawn from public discussion. They are not derived from any trial and are not evidence that a dose is safe or effective.

Cycling

Community practice

4 to 8 weeks on, 4 weeks or more off.

No study establishes an optimal cycle length, or that cycling is necessary at all. These figures describe what is commonly reported rather than what has been tested.

Work out what to draw

Pre-filled with a 5 mg vial as a worked example. These are not recommended values — change them to match the vial in front of you.

Tool

Draw to 10 units on a 1 mL U-100 syringe. That is 0.1 mL, containing 250 mcg of BPC-157.

Concentration2.5mg / mL

Volume drawn0.1mL

Doses per vial20doses

Per unit25mcg / unit

10 units sits exactly on a printed line.

Get a shareable image Read the profile

BioAlmanac performs arithmetic on values you enter. It does not recommend doses, schedules or compounds, and nothing here is medical advice. Confirm every calculation against your vial and syringe before drawing, and speak with a licensed healthcare provider.

Open this calculation in the full calculator

Units, concentration, bacteriostatic water — the glossary defines the vocabulary, and a unit is not a fixed volume.

Safety

Reported effects, the situations that need care, and the ones that mean stop.

Read before dosing

Reported effects

Injection site redness, itching or irritationCommunity practice
Commonly reported
The most frequently described effect. Rotating sites reduces it.
Lightheadedness or flushing shortly after injectionCommunity practice
Occasionally reported
Nausea or changes in appetiteCommunity practice
Occasionally reported
Long-term effectsCommunity practice
Unknown
No human safety study of any duration has been published. Absence of reported harm is not evidence of safety. It reflects the fact that nobody has looked systematically.

When to stop

Any sign of infection at an injection site: spreading redness, warmth, swelling, pus, or fever.
A rash, hives, swelling of the face or lips, or any difficulty breathing. Seek urgent medical care.
Injection site reactions that worsen with each dose rather than settling.
Any new or unexplained symptom you would normally see a doctor about. Stop first, then get it looked at.
Before any planned surgery, and tell your surgeon. A compound proposed to promote blood vessel growth is relevant information for them.

Interactions and situations that need care

Anticoagulants and antiplatelet drugsUse caution
BPC-157's most-cited proposed mechanism is promoting new blood vessel formation. How that interacts with drugs that alter clotting has not been studied, and the question is a real one, not a formality. Discuss it with the prescriber who manages your anticoagulation.
Active or previous cancerUse caution
Angiogenesis, the growth of new blood supply, is also a process tumours depend on. No study has examined BPC-157 in people with cancer, in either direction. The absence of data is the reason for caution, not a finding.
Pregnancy and breastfeedingAvoid
No reproductive or developmental safety data exists in humans.
Competing in a tested sportAvoid
Prohibited at all times by the World Anti-Doping Agency under S0, with no therapeutic use exemption available.
Children and adolescentsAvoid
No safety data in any age group, and none at all in minors.

SportProhibited by the World Anti-Doping Agency under S0: Non-Approved Substances, at all times. No therapeutic use exemption is available for substances in S0, because they hold no regulatory approval for human use anywhere.

What to expect

What the sources describe over time, and how confident anyone can be about it.

No human efficacy data

HonestlyThere is no human efficacy data for this compound, so there is no evidence-based timeline to give. Any site publishing a week-by-week schedule of expected effects has invented it.

There is no human efficacy data, so there is no honest timeline to give you. Anyone publishing a week-by-week schedule of expected effects for BPC-157 has invented it.
What people report anecdotally varies enormously, and anecdote cannot separate a real effect from the natural course of an injury that was going to improve anyway.
Injuries heal on their own. Attributing recovery to a compound taken during recovery is the single hardest thing to get right without a control group.
If you use it, decide in advance what you would count as a result and write down where you started. Nothing else will let you learn anything from your own experience.

Storage and combinations

How to keep it, and what it does and does not go with.

Printable one-pager →

Storage and handling

Freeze-dried powder: Refrigerated at 2–8 °C, protected from light. The freeze-dried powder is considerably more stable than the mixed solution.
After mixing: Refrigerated at 2–8 °C. Do not freeze once mixed. Discard if the solution becomes cloudy.
Long-term, frozen: Unopened lyophilised powder can be held at −20 °C or colder, sealed and protected from light, for far longer than refrigeration allows.

Printable one-pager How to reconstitute a vial, step by step

With other peptides

TB-500synergistic
Frequently combined in community protocols on the reasoning that they act through different repair pathways. No controlled study has tested the combination.
Thymosin Beta-4synergistic
The full protein that TB-500 is a fragment of, and the same pairing logic applies: new blood vessels alongside cell migration. Coherent as a mechanism, untested as a combination.

Check this against a whole stack

Stacks with BPC-157 in them

Documented combinations and plans people have published, with full schedules.

Documented combinations, with full schedules.

Published by people running it. Their plans, not ours — one person doing something is not evidence that it works.

Checking your vial

Research chemicals carry no manufacturing standard, so what the vial looks like is often the only quality signal available before you use it.

Quality and COAs →

White, fluffy cake
Properly freeze-dried powder sits as a light cake covering the bottom of the vial.
Clear once mixed
After gentle swirling the solution should be completely clear, with no visible particles.
Loose or slightly clumped powder
Shipping shakes vials. Small clumps that dissolve completely on gentle swirling are not a problem.
Collapsed, melted or stuck to the sides
A cake that has slumped or fused to the glass suggests the vial got warm in transit. Heat damage cannot be undone by refrigerating it afterwards.
Cloudy or particulate after mixing
Persistent cloudiness or floating material after gentle swirling indicates degraded or contaminated material.

Vocabulary on this page

Insulin syringe: A small syringe graduated in units rather than millilitres, most commonly with a U-100 scale.
Cycling: Running a compound for a defined period and then stopping for one, rather than taking it continuously.
Bacteriostatic water: Sterile water containing a small amount of benzyl alcohol, which stops bacteria multiplying and allows a vial to be used more than once.
Lyophilised: Freeze-dried. The process used to turn a peptide solution into a stable dry powder for shipping and storage.
Subcutaneous: Into the layer of fat beneath the skin rather than into muscle. The route almost every peptide on this site uses.
Unit: A mark printed on an insulin syringe. A unit is not a fixed volume. What it represents depends entirely on the syringe's scale.

The whole glossary →

Questions

Reader questions

Is there human evidence for BPC-157?: There are no completed, published, controlled human trials establishing that it works or that it is safe. One small uncontrolled pilot in interstitial cystitis with twelve participants exists. The rest of the evidence base is animal studies, largely from a small number of research groups, without independent replication in people.
Why is it sold as a research chemical?: Because it is not an approved medicine. That label means the material has not been manufactured, tested or labelled to any pharmaceutical standard, and purity and identity vary between sellers.
How is BPC-157 usually reconstituted?: A 5 mg vial mixed with 2 mL of bacteriostatic water gives 2.5 mg per mL, which puts a 250 mcg dose at 10 units on a 1 mL U-100 syringe. Use the calculator on this page to check your own numbers against your own vial.
Does injecting near the injury actually matter?: It is very commonly recommended in community sources, on the reasoning that the effect is local. No human study has compared injecting near an injury against injecting elsewhere, so this is a plausible idea, not an established one.

References

Everything on this page that came from a source, with the source.

Stable Gastric Pentadecapeptide BPC 157: Novel Therapy in Gastrointestinal Tract
Current Pharmaceutical Design, 2011 · Narrative review of preclinical work
Rats and mice
Summarises reported healing effects across tendon, muscle and gastrointestinal injury models, and proposes angiogenesis and nitric oxide signalling as mechanisms.
10.2174/138161211798109613
Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications
Current Neuropharmacology, 2016 · Review
Rats
Reviews cytoprotective effects on the gastric lining in induced-injury rodent models.
10.2174/1570159X13666160502153022
Commonly reported community protocols
BioAlmanac editorial summary of public community sources, 2026 · Not a study
Summarises the dose ranges and cycle lengths most consistently described in public discussion. Carries no evidential weight about safety or effect, and is recorded here only so readers can see what is commonly done and judge it as such.
Compiled community protocols
BioAlmanac editorial summary of a public protocol compilation, 2026 · Not a study
Records a week-by-week progression described on a vendor-adjacent protocol site, retrieved August 2026. Only the doses are taken from it. Its own syringe-unit conversions were checked against the vial sizes it states and several understate the volume by half, so nothing computed by that source is reproduced here — the units on this site are worked out from the vial in front of you. Carries no evidential weight about safety or effect.

Quick reference

Commonly described dose: 250 mcg–500 mcg
How often: Once or twice daily
Route: Subcutaneous or Intramuscular
Where: Abdomen, Thigh, Upper arm, Near the injury site
Timing: Frequently reported on an empty stomach. There is no human study supporting a timing preference.
Half-life: Around 4 hours in animal studies; not established in humans
Storage once mixed: Refrigerated, 30 days
Cycle: 4 to 8 weeks on, 4 weeks or more off

These describe what sources report, not what you should do. Full detail and provenance in the dosing section below.

Price index

$1.80 – $119.99per mg

Across 59 vendors, normalised per milligram and confirmed by a person. Compared against other injectable vials only — a capsule bottle holds far more milligrams than a vial, so the two are not one market.

SizeIn stock only

Confirmed listings for this compound, cheapest per milligram first.
Vendor	Size
Reta One Labs	20 mg	$36.00	$1.80
S1Research	10 mg	$19.75	$1.98
S1Research	30 mg	$60.00	$2.00
Nexus Peptides	5 mg × 10 vial	$109.99	$2.20
Reta One Labs	10 mg	$22.00	$2.20

Show 105 more vendors

The remaining listings, continuing from cheapest.
PeptidePlugs	20 mg	$50.00	$2.50
Alpha Peptides	10 mg	$27.29	$2.73
IDUN Peptides	10 mg	$27.99	$2.80
OneDay Compounds	10 mg	$27.99	$2.80
Puratek Peptides	10 mg	$29.95	$3.00
Glacier Aminos	20 mg	$59.99	$3.00
Peptide Giants	10 mg × 10 vial	$299.99	$3.00
Liberty Peptides	20 mg	$61.75	$3.09
Direct Peptides	10 mg	£34.38	$3.44
Glacier Aminos	10 mg	$34.49	$3.45
Genpeptide	10 mg	$35.00	$3.50
Evolve BioPep	10 mg	$35.00	$3.50
Ameano Peptides	10 mg	$35.00	$3.50
Liberty Peptides	10 mg	$35.10	$3.51
Sentinel Valor	10 mg	$35.99	$3.60
Nexus Peptides	5 mg × 10 vial	$179.99	$3.60
Peptide Giants	10 mg	$36.00	$3.60
Direct Peptides	5 mg	£18.33	$3.67
Elite Edge Biotech	10 mg	$38.00	$3.80
Peptide Giants	5 mg	$19.99	$4.00
Licensed Peptidesout of stock	10 mg × 10 vial	$399.99	$4.00
TCore Biotech	10 mg	$44.99	$4.50
Legendary Peptides	10 mg	$45.00	$4.50
Prime Lab Peptides	10 mg × 10 vial	$455.00	$4.55
Elite Edge Biotech	5 mg	$23.00	$4.60
Paramount Peptides	20 mg	$96.05	$4.80
Protide Health	40 mg	$195.00	$4.88
Ascension Peptides	10 mg	$49.00	$4.90
Nura Peptide	10 mg	$49.00	$4.90
Vital Core Research	10 mg	$49.99	$5.00
Rescue Research USAout of stock	10 mg	$49.99	$5.00
Licensed Peptides	30 mg	$149.99	$5.00
Reserve Research	10 mg	$50.00	$5.00
Ignite Peptides	10 mg	$50.00	$5.00
Longevity Pro Labs	10 mg	$50.00	$5.00
Happy Peps	10 mg	$50.00	$5.00
Happy Peps	10 mg	$50.00	$5.00
Happy Peps	10 mg	$50.00	$5.00
Happy Peps	10 mg	$50.00	$5.00
Sentinel Valor	5 mg	$25.99	$5.20
Verified Peptides	10 mg	$53.00	$5.30
Liberty Peptides	10 mg	$54.00	$5.40
Peak Lab Peptides	10 mg	$54.40	$5.44
NuScience Peptides	20 mg	$109.00	$5.45
Felix Chemical Supply	10 mg	$54.99	$5.50
Nexus Peptides	2 mg × 10 vial	$109.99	$5.50
Prime Peptides	10 mg	$55.00	$5.50
Protide Health	20 mg	$110.00	$5.50
Prime Lab Peptides	10 mg	$55.00	$5.50
Blank Peptides	10 mg	$55.00	$5.50
Direct Peptides	2 mg	£11.46	$5.73
Swiss Chems	10 mg	$59.95	$6.00
Koi Peptidesout of stock	10 mg	$59.95	$6.00
Vital Core Research	6 mg	$35.99	$6.00
Apollo Peptide Sciencesout of stock	10 mg	$59.99	$6.00
NuScience Peptides	10 mg	$59.99	$6.00
Polaris Peptides	10 mg	$60.00	$6.00
Penguin Peptides	10 mg	$62.00	$6.20
AminoVault	10 mg	$62.05	$6.21
Nationwide Peptides	10 mg	$63.00	$6.30
Paramount Peptides	10 mg	$63.75	$6.38
TCore Biotech	5 mg	$32.39	$6.48
Protide Health	10 mg	$65.00	$6.50
Xeno Peptides	10 mg	$65.00	$6.50
Peak Lab Peptides	5 mg	$33.40	$6.68
Licensed Peptidesout of stock	5 mg × 10 vial	$337.50	$6.75
Modern Aminos	10 mg	$68.00	$6.80
Kylo Peptides	10 mg	$69.95	$7.00
NuScience Peptides	5 mg	$34.99	$7.00
Polaris Peptides	5 mg	$35.00	$7.00
BulkGLP	10 mg	$70.00	$7.00
Paramount Peptides	10 mg	$75.00	$7.50
Modern Aminos	5 mg	$38.00	$7.60
Koi Peptidesout of stock	5 mg	$39.95	$7.99
Swiss Chems	5 mg	$39.99	$8.00
Penguin Peptides	5 mg	$42.00	$8.40
Nationwide Peptides	5 mg	$42.00	$8.40
Life Link Research	10 mg	$89.00	$8.90
PSPeptides	10 mg	$89.99	$9.00
Biotech Peptides	10 mg	$92.00	$9.20
Paramount Peptides	5 mg	$46.75	$9.35
Peptide Pros	5 mg	$47.25	$9.45
Core Peptides	10 mg	$97.00	$9.70
Kylo Peptides	5 mg	$49.95	$9.99
BioLongevity Labs	10 mg	$99.97	$10.00
PSPeptides	5 mg	$49.99	$10.00
Pure Bio Labs	10 mg	$99.99	$10.00
Apex Peptides	10 mg	$100.00	$10.00
Core Peptides	5 mg	$52.00	$10.40
Biotech Peptides	5 mg	$52.00	$10.40
Biotech Peptides	5 mg	$52.00	$10.40
Elite Biogenix	10 mg	$104.99	$10.50
Elite Biogenix	20 mg	$210.99	$10.55
Sports Technology Labs	5 mg	$54.99	$11.00
Elite Biogenix	5 mg	$54.99	$11.00
Apex Peptides	5 mg	$55.00	$11.00
Vital Core Research	2 mg	$30.99	$15.49
Pure Bio Labs	5 mg	$79.99	$16.00
Royal Peptides	20 mg	$580.00	$29.00
Nexus Peptides	10 mg	$339.99	$34.00
Royal Peptides	10 mg	$360.00	$36.00
Royal Peptides	10 mg	$400.00	$40.00
Nexus Peptides	5 mg	$204.99	$41.00
Nexus Peptides	2 mg	$109.99	$54.99
Umbrella Labs	1 mg	$119.99	$119.99

Is this price moving? →Every compound we price →

Average per mg

30 daysAll

We started tracking more vendors during this window, so part of this line is who we track rather than what they charge.

Lowest ever: $1.80 11 Oct 2026
Highest ever: $59.95 1 Sept 2026
Change: 30 → 48 vendors 13 Sept to 13 Oct

We started tracking more vendors during this window, so part of this line is who we track rather than what they charge.

Lowest ever: $1.80 11 Oct 2026
Highest ever: $59.95 1 Sept 2026
Change: 6 → 48 vendors 24 Aug to 13 Oct

Mean of each vendor’s cheapest vial listing, US dollars only. Full chart

Email me when BPC-157 gets cheaper

Ranked on price alone. We sell nothing, take no payment for placement, and use no affiliate links — listing a price is not a recommendation to buy. Prices are what the vendor listed when we last looked, not a live quote.

Cold chain

Freeze-dried: Refrigerated at 2–8 °C, protected from light. The freeze-dried powder is considerably more stable than the mixed solution.
After mixing: Refrigerated at 2–8 °C. Do not freeze once mixed. Discard if the solution becomes cloudy.
Long-term, frozen: Unopened lyophilised powder can be held at −20 °C or colder, sealed and protected from light, for far longer than refrigeration allows.

How to reconstitute a vial

Stop and seek advice

Any sign of infection at an injection site: spreading redness, warmth, swelling, pus, or fever.
A rash, hives, swelling of the face or lips, or any difficulty breathing. Seek urgent medical care.
Injection site reactions that worsen with each dose rather than settling.
Any new or unexplained symptom you would normally see a doctor about. Stop first, then get it looked at.
Before any planned surgery, and tell your surgeon. A compound proposed to promote blood vessel growth is relevant information for them.

The full safety section carries the sources for these.

BPC-157 compared with

BPC-157 vs Thymosin Beta-4

The two halves of the repair pairing, compared instead of combined. This is also where the TB-500 naming confusion does the most damage.

BPC-157 vs TB-500

Two research peptides discussed for tissue repair. Both rest on animal evidence, and they differ in proposed mechanism and in dose scale.

Also compared with GHK-Cu, KPV, LL-37, ARA-290, Thymulin, VIP.

Related compounds

TB-500

A synthetic fragment of thymosin beta-4, a naturally occurring protein involved in cell migration and tissue repair. Animal evidence only.

Thymosin Beta-4

The full 43-amino-acid protein that TB-500 is a fragment of. It reached phase 2 trials in humans. TB-500 never has.

GHK-Cu

A naturally occurring copper-binding tripeptide with a long history in topical skincare research. Injected use is not what the research studied.

KPV

A three-amino-acid fragment of alpha-MSH studied for anti-inflammatory effects, largely in animal models of gut inflammation.

Keep this page honest

If something here is wrong, out of date, or missing a source, tell us and we will fix it and say that we did.

Suggest a correction

This page is educational. It describes what published research reports, not what you should do. Peptides discussed here are largely not approved for human use, and nothing on BioAlmanac is medical advice. No clinician reviews these pages.

Page last updated 12 Aug 2026